Plain-language, educational articles on schizophrenia, psychosis, antipsychotic medications, and lived experience — by ColdAI.
Pregnancy on an antipsychotic is rarely a simple yes-or-no decision. Here is what the research actually shows — and how perinatal psychiatrists think about the trade-offs.
DelusionsReligious delusions occupy a difficult space — they often look like fervent faith from the outside and feel like revelation from the inside. The clinical task is to distinguish them from healthy spiritual life and treat them with care.
Caregiver scenariosEstrangement and schizophrenia often travel together. Here is how to think about contact, safety, and the kind of help you can offer when a relationship has already broken.
Lab monitoringSeveral antipsychotics raise prolactin, sometimes silently. Knowing when to test, what counts as high, and what the options are takes the mystery out of one of the most common lab findings on these medications.
LifestyleCaffeine is the most common psychoactive drug in the world, and it interacts in real ways with several antipsychotics — particularly clozapine. A practical guide.
Practical lifeA weekly pillbox is one of the cheapest, highest-impact tools for staying on antipsychotic medication. Here is how to choose one and load it without losing an evening.
Therapy modalitiesAVATAR therapy is one of the strangest and most studied new treatments for distressing voices. The patient sits in front of a screen, the therapist gives the voice a face, and the conversation that follows can be the first one the patient has ever felt they could win.
DifferentialSchizophrenia and psychopathy get blurred together in headlines and movies, but they are different conditions in different chapters of the diagnostic manual. Here is what each one actually is.
Special populationsRoughly one in seven people in US jails has a serious mental illness — and people with schizophrenia are far more likely to end up incarcerated than the general population. Here is what to know about rights, care, and reentry.
Side effectsExtrapyramidal symptoms are the family of movement side effects produced by dopamine-blocking medications. Understanding the four sub-types — and how they overlap — changes how they get treated.
Drug interactionsCaffeine is the most commonly consumed psychoactive substance in the world — and it shares a metabolic pathway with several antipsychotics. Here is what to actually know.
Brain circuitsThe hippocampus is one of the most consistently affected brain regions in schizophrenia. Smaller volumes, regional hyperactivity, and CA1 dysfunction appear early and may help drive dopamine abnormalities downstream.
Expressive therapiesArt therapy is more than 'doing art.' It is a structured psychological therapy in which images become a way to think about experiences that are hard to put into words.
HousingSupported housing is not one thing — it is a spectrum of arrangements ranging from a private apartment with a visiting case manager to a fully staffed group home. Choosing the right rung matters enormously.
SleepSleep in schizophrenia is not just disturbed — its architecture is measurably different. Reduced slow-wave sleep, fewer sleep spindles, and shifted REM are now well documented in the literature.
ResearchGenome-wide association studies have identified hundreds of genetic loci linked to schizophrenia. Here is what those findings mean — and what they still cannot tell us.
Medical comorbidityType 2 diabetes is two to three times more common in people with schizophrenia than in the general population — and it is dramatically under-screened, under-diagnosed, and under-treated.
MedicationChlorpromazine, sold as Thorazine in the US and Largactil in Europe, was the first antipsychotic and remains a working option in 2026 — usually for specific situations rather than first-line use.
MedicationChlorpromazine started the modern era of antipsychotics in 1954. Its side effect profile is broad and well-mapped — sedation, low blood pressure, dry mouth, sun sensitivity, and more.