Foundational guides to understanding schizophrenia, psychosis, and how the condition affects daily life.
The prefrontal cortex underlies the cognitive symptoms of schizophrenia. Reduced volume, lower activation during effortful tasks, and altered GABA interneuron function are among the most consistent findings.
ResearchRoughly one in four people with 22q11.2 deletion syndrome develops schizophrenia or a related psychotic disorder. The condition is the strongest single genetic risk factor for schizophrenia known.
DisparitiesReligious belief is woven through how many patients with schizophrenia experience and explain their illness. For minority faith communities, mainstream psychiatry often misses both the strength and the specificity.
GeriatricLong-term care for older adults with schizophrenia is one of the hardest navigation challenges in mental health. Here's what families and clinicians need to understand about the system.
Brain circuitsThe thalamus relays nearly every sensory and cortical signal in the brain. In schizophrenia, parts of the thalamus shrink, its connections rewire, and signals between thalamus and cortex become less coordinated.
ResearchPolygenic risk scores compress hundreds of small-effect schizophrenia variants into a single number. Useful in research, not yet ready for the clinic.
DifferentialThe 'split mind' translation of schizophrenia has fuelled a century of confusion with dissociative identity disorder. Here is what actually separates the two conditions.
DifferentialSchizophrenia and psychopathy get blurred together in headlines and movies, but they are different conditions in different chapters of the diagnostic manual. Here is what each one actually is.
Brain circuitsThe hippocampus is one of the most consistently affected brain regions in schizophrenia. Smaller volumes, regional hyperactivity, and CA1 dysfunction appear early and may help drive dopamine abnormalities downstream.
ResearchGenome-wide association studies have identified hundreds of genetic loci linked to schizophrenia. Here is what those findings mean — and what they still cannot tell us.